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Contracted laboratory for Biomarkers

BIOANALYTICA GENOTYPE SA was established in December 2004 as a biotech startup aiming to provide specialised molecular cytogenetic research and application services to the biomedical Community.

 

Was funded by BIOANALYTICA SA, a leading stakeholder in the greek market for molecular diagnostics and laboratory infrastructure, and by the researcher Dr. Georgia Bardi, Associate Professor of Experimental Clinical Genetics at the Medical school of Lund University, Sweden and former Director of the Cytogenetics facility at Saint Savas Oncology hospital of Athens.

 

Is co-financed by the Greek General Secretariat of Research and Technology under the 3rd Community Support Program (03 Praxe 26).

 

 

HAEMATOLOGICAL NEOPLASMS

HAEMATOLOGICAL NEOPLASMS

                              HAEMATOLOGICAL NEOPLASMS
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Bone Marrow Karyotype G-Banding 3-5ml of bone marrow in heparin tube  15-25°C 15
XX / XY Chimerism (after allogeneic bone marrow transplantation) FISH CE IVD 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 4
Sequencing of the hotspot and exon regions in 54 identified genes of diagnostic significance for the neoplasms of the myeloid cell line: ABL1 (ex 4-6), ASXL1 (ex12), ATRX (ex 8-10 & 17-31), BCOR, BCORL1,  BRAF (ex 15), CALR (ex 9), CBL (ex 8,9), CBLB (ex 9, 10), CBLC (ex 9, 10), CDKN2A,  CEBPA, CSF3R (ex 14–17), CUX1, DNMT3A, ETV6/TEL, EZH2, FBXW7 (ex 9 + 10 + 11), FLT3 (14 + 15 + 20), GATA1 (ex 2), GATA2 (ex 2-6), GNAS (ex 8+9), HRAS (ex 2+3), IDH1 (ex 4), IDH2 (ex 4), IKZF1, JAK2 (ex 12+14), JAK3 (ex 13), KDM6A, KIT (ex 2, 8–11, 13+17),  KRAS (ex2,3), MLL (ex 5-8),  MPL (ex 10), MYD88 (ex 3-5), NOTCH1 (ex 26-28 + 34), NPM1 (ex 12), NRAS (ex 2,3), PDGFRA (ex 12, 14, 18), PHF6, PTEN (ex 5 + 7), PTPN11 (ex 3 + 13), RAD21, RUNX1, SETBP1 (ex 4 partial), SF3B1 (ex 13-16), SMC1A  (ex 2, 11, 16 + 17), SMC3 (ex 10, 13, 19, 23, 25 + 28),  SRSF2 (ex 1), STAG2, TET2 (ex 3-11), TP53 (ex2-11), U2AF1 (ex 2+6), WT1 (ex 7+9), ZRSR2. NGS 1-2ml of bone marrow/3-5ml of blood in EDTA tube 12
CHRONIC MYELOGENOUS LEUKEMIA (CML)
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
BCR-ABL detection (p210 & p190) Nested PCR  1-2ml of bone marrow/3-5ml of blood in EDTA tube 3  
BCR-ABL quantification t(9;22)(q34;q11) Real Time PCR  1-2ml of bone marrow/3-5ml of blood in EDTA tube 3 
BCR-ABL FISH  1-2ml of bone marrow/3-5ml of blood in EDTA tube 5  
 ABL Mutations  Sequencing  1-2ml of bone marrow/3-5ml of blood in EDTA tube 20
ABL deletion, del(9q34) FISH  1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5  
i(17q) FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5  
Trisomy 8 FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5  
Trisomy 19 FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5  
CML TEST COMBINATIONS Method Specimen Type  Turnaround Time (business days) 
A: Bone Marrow karyotype & BCR-ABL1 quantification  G-banding και Real Time PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 15/3 
B: BCR-ABL1 quantification & BCR-ABL mutations  Real Time PCR, Sequencing 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 3/20 
C: Bone Marrow karyotype & BCR-ABL1 quantification, BCR-ABL mutations - ΤΚΙ resistance G-banding και Real Time PCR & Sequencing 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 15/3/20 
D: Trisomy 8, Isochromosoma 17, Trisomy 19 3xFISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5 
MYELOPROLIFERATIVE DISEASES
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
JAK2 V617F ARMS PCR  1-2ml of bone marrow/3-5ml of blood in EDTA tube 2 
JAK2 exon 12 Sequencing  1-2ml of bone marrow/3-5ml of blood in EDTA tube 20
CALR exon 9 Sequencing  1-2ml of bone marrow/3-5ml of blood in EDTA tube 20
MPL W515L/K Real Time PCR   1-2ml of bone marrow/3-5ml of blood in EDTA tube 5 
BCR-ABL detection (p210 & p190) Nested PCR  1-2ml of bone marrow/3-5ml of blood in EDTA tube 3 
c-kit D816V Sequencing  1-2ml of bone marrow/3-5ml of blood in EDTA tube 5
PDGFRB t(5;?)(q33;?) (various partners) FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
FIP1L1-PDGFRA (4q12) FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
FGFR1/8p11-12 FISH 1-2 ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
MYELOPROLIFERATIVE DISEASE TEST COMBINATIONS Method Specimen Type  Turnaround Time (business days) 
A: Polycythemia vera (PV): BCR-ABL1 detection, JAK2 (V617F), JAK2 exon 12 Nested PCR, ARMS PCR, Sequencing   1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/2/20
B: Essential thrombocythemia (ΕΤ): BCR-ABL1 detection, JAK2 (V617F), CALR, MPL (W515) Nested PCR, ARMS PCR, Sequencing, Real-Time PCR    1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/2/20/5
C: Primary myelofibrosis (PMF): JAK2 (V617F), CALR, MPL (W515) Nested PCR,  Sequencing, Real-Time PCR    1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/20/5
D: Chronic Eosinophilic Leukemia (CEL): FIP1L1-PDGFRA, PDGFRΒ, FGFR1, c-ΚΙΤ (D816V), CBFB/inv(16) 4xFISH, Sequencing  1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 5
E: Karyotype, BCR-ABL1 detection, JAK2 (V617F) G-banding, ARMS PCR, Nested PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/3/2
F: Karyotype, BCR-ABL1 detection , JAK2 (V617F), FIP1L1-PDGFRA, PDGFRB, FGFR1 G-banding, ARMS PCR, Nested PCR, 3xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/3/2/5/5/5
MYELODYSPLASTIC SYNDROMES
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
-5/5q- FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
-7/7q- FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
20q- FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
+8 FISH CE/IVD 1-2ml of bone marrow in heparin tube 15-25°C 5
P53/ del(17)(p13.1) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
MDS Test Combinations Method Specimen Type  Turnaround Time (business days) 
A: 5/5q-, 7/7q- 2xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
B: 5/5q-, 7/7q-,trisomy 8 3xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
C: 5/5q-, 7/7q-, trisomy 8, TP53 4xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
D: 5/5q-, 7/7q-, trisomy 8, TP53, 20q-                                                   5xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
E: Karyotype, 7/7q- G-banding, 1xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
F: Karyotype, 7/7q-, 20q- G-banding, 2xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
G: Karyotype, 7/7q-, 20q-, 5/5q G-banding, 3xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
H: Karyotype, 7/7q-, 20q-, 5/5q-, trisomy 8 G-banding, 4xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
I: Karyotype, 7/7q-, 20q-, 5/5q-, trisomy 8, TP53 G-banding, 5xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/6
ACUTE MYELOGENOUS LEUKEMIA
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
AML/ETO quantification/t(8;21)(q22;q22) Real-Time PCR 1-2ml of bone marrow in EDTA tube 2
PML/RARa detection (bcr1 or bcr2 or bcr3) Real-Time PCR 1-2ml of bone marrow in EDTA tube 1 
PML/RARa detection (bcr1, bcr2, bcr3) Real-Time PCR 1-2ml of bone marrow in EDTA tube 1 
PML/RARa  bcr1 quantitive, t(15;17)(q22;q21) Real-Time PCR 1-2ml of bone marrow in EDTA tube 3
PML/RARa  bcr2 quantitive, t(15;17)(q22;q21) Real-Time PCR 1-2ml of bone marrow in EDTA tube 3
PML/RARa bcr3 quantitive, t(15;17)(q22;q21) Real-Time PCR 1-2ml of bone marrow in EDTA tube 3
RARa/ 17q21 (various partners) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
ETO(CBFA2T1)-AML1(RUNX1 or CBFA2), t(8;21)(q22;q22) FISH  1-2ml of bone marrow in heparin tube 15-25°C 5
CBFb-MYH11  inv(16)(p13q22) t(16;16)(p13;q22) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
MLL /(11q23) (various partners) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
3q26/ inv(3) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
DEK/NUP214(CAN) t(6;9) FISH 1-2ml of bone marrow in heparin tube 15-25°C 5
CEBPA mutations PCR & RNA Sequencing 1-2ml of bone marrow/3-5ml of blood in EDTA tube 20
+8 FISH CE/IVD 1-2ml of bone marrow in heparin tube 15-25°C 5
WT1 quantification QRT-PCR 1-2ml of bone marrow in EDTA tube 5
FLT3 (ITD, D835) PCR-RFLP 1-2ml of bone marrow in EDTA tube 3
NPM1 Fragment Analysis 1-2ml of bone marrow in EDTA tube 3
c-kit ex8, ex17 Sequencing 1-2ml of bone marrow in EDTA tube 5
IDH1/2 Mutations in exon 4 [(IDH1 R100Q & R132H/C/S/G/L/V) (IDH2 R172K/M/W/S/G)  RNA Sequencing   Tissue biopsy/ 6-8 paraffin embedded tissue slides of 10μm, 15-25°C 15
AML Test Combinations Method Specimen Type  Turnaround Time (business days) 
A: FLT3(ITD, D835), NPM1 PCR-RFLP, Fragment Analysis 1-2ml of bone marrow in EDTA tube 3
B: Καρυότυπος, RARa/17q21 (όλες οι ανακατατάξεις) G-banding, 1xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
C: Καρυότυπος, RUNX1-RUNX1T1 (AML1-ETO) G-banding, 1xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
D: Καρυότυπος, CBFΒ-MYH11/inv(16)(p13q22) ή t(16;16)(p13;q22) G-banding, 1xFISH 1-2ml of bone marrow in heparin tube 15-25°C 15/5
E: PML-RARa, CBFΒ/inv16, KMT2A (MLL) Real-Time PCR, 2xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 1/5
F: RARa, CBFΒ/inv16, KMT2A (MLL) 3xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
G: RARa, CBFΒ/inv16, KMT2A (MLL), RUNX1-RUNX1T1 (AML1-ETO)  4xFISH 1-2ml of bone marrow in heparin tube 15-25°C 5
H: PML-RARa, CBFΒ/inv16, KMT2A (MLL), RUNX1-RUNX1T1 (AML1-ETO)  1xReal-Time PCR, 3xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 1/5
B CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
ETV6 (TEL) t(12;?)(p13;?) (various partners) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
BCR-ABL t(9;22)(q34;q11) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
MLL rearrangements t(11;?)(q23;?),(various partners)  FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
p16 (CDKN2a)/ del(9p21)/CEP 9 FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
c-MYC t(8q24) (various partners) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
TEL/AML1 quantification t(12;21)(p13;q22) Real-Time PCR 3-5ml of bone marrow in EDTA tube 5
BCR-ABL detection (p210 & p190) Nested PCR 1-2ml of bone marrow/3-5ml of blood in EDTA tube 3
 ABL Mutations  Sequencing 1-2ml of bone marrow/3-5ml of blood in EDTA tube 20
IKZF1, IKAROS del/mutations MLPA 1-2ml of bone marrow/3-5ml of blood in EDTA tube 5
ALL Test Combinations Method Specimen Type  Turnaround Time (business days) 
A: BCR-ABL detection (p210 & p190),
ETV6 (TEL)(12;?)(p13;?) (all rearrangements),
KMT2A (MLL) rearrangements t(11;?)(q23;?), (all rearrangements) 
1xNested PCR and 2xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/5 
B: Karyotype, BCR-ABL t(9;22)(q34;q11) quantification G-banding and Real-Time PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/5 
C: Karyotype, BCR-ABL detection (p210 & p190) G-banding and Nested PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/3
D: Karyotype, TEL-AML1 quantification t(12;21)(p13;q22) G-banding and Real- Time PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/5 
E: Karyotype, KMT2A (MLL) rearrangements t(11;?)(q23;?), (all rearrangements)  G-banding and FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/5 
F: BCR-ABL detection (p210 & p190), TEL/AML1 quantification t(12;21)(p13;q22), KMT2A (MLL) t(11;?)(q23;?) (all rearrangements) 1xNested PCR, 1xReal-Time PCR and 1xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/5 
G: BCR-ABL detection (p210 & p190),
TEL/AML1 quantification t(12;21)(p13;q22),
KMT2A (MLL) t(11;?)(q23;?) (all rearrangements)
c-MYC t(8q24) (all rearrangements)
1xNested PCR, 1xReal-Time PCR and 2xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 3/5 
H: Karyotype, BCR-ABL detection (p210 & p190), TEL/AML1 quantification t(12;21)(p13;q22), KMT2A (MLL) t(11;?)(q23;?), (all rearrangements) G-banding, 1xNested PCR, 1xReal-Time PCR and 1xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C, 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15/3/5 
CHRONIC LYMPHOCYTIC LEUKEMIA  
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
IgVH Hypermutations Sequencing 1-2ml of bone marrow/3-5ml of blood in EDTA tube 10
P53 /del(17)(p13.1) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
TP53 σωματικές μεταλλάξεις  NGS 1-2ml of bone marrow/3-5ml of blood in EDTA tube 10
ATM (11q22.3) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
del(13)(q14.3) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
+12 FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
SEC63 / del(6)(q21) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
CCND1-IgH/ t(11;14) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
CLL Test Combinations Method Specimen Type  Turnaround Time (business days) 
A: P53, ATM  MLPA  1-2ml of bone marrow/3-5ml of blood in EDTA tube 5  
B: del13-q14.3, ATM, P53, +12, 6q-, NOTCH1, SF3B1 MLPA 1-2ml of bone marrow/3-5ml of blood in EDTA tube 5  
C: IgVH Hypermutations, del13-q14.3, ATM, P53, +12, 6q-, NOTCH1, SF3B1 Sequencing and MLPA 1-2ml of bone marrow/3-5ml of blood in EDTA tube 5  
D: Karyotype and P53, ATM  G-banding and MLPA  1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 15/5 
E: Karyotype and del13-q14.3, ATM, P53, +12, 6q-, NOTCH1, SF3B1 G-banding and MLPA  1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 15/5
F: ATM, P53 2xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5 
G: BCL1-IH(CCND1-IgH) /t(11;14), IgH-BCL2/ t(14;18) 2xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5 
H: del(13q)(14.3), ATM, TP53, CEP12 4xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5 
I: IgVH Hypermutations, del(13q)(14.3) , ATM, TP53, CEP12, t(11;14 Sequencing and 5xFISH 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 10
HAIRY CELL LEUKEMIA
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
BRAF Mutation V600E/K Real-Time PCR 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 3
 IgVH Hypermutations  Sequencing 1-2ml of bone marrow/3-5ml of blood in heparin tube and 1-2ml of bone marrow in EDTA tube 15-25°C 10
MULTIPLE MYELOMA & RELATED DISEASES
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
FGFR3 -IGH / t(4;14)(p16;q32) 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
IGH-c-maf / t(14;16)(q32;q23) 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
ΙGH-MAFB/ t(14;20)(q32;q12)  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
CCND1(BCL1)-IGH /t(11;14)(q13q32)  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
IGH/CCND3 /t(6;14)(p21;q32) 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
IGH (14q32) (all rearrangements)  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
c-MYC (8q24) (all rearrangements) 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
TP53 /del(17)(p13.1)  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
amp 1q21  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
del(13)(q14) 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
Trisomy 5, 9 and 15 1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
MM Test Combinations Method Specimen Type  Turnaround Time (business days) 
A: TP53, IgH -FGFR3 2xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
B: del13q14, TP53, IgH-FGFR3 3xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
C: del13q14, TP53, IgH-FGFR3, IgH-cMaf 4xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
D: 13q, TP53, IgH-FGFR3, IgH-cMAf, 1q21 5xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
E: del13q14, TP53, IgH-FGFR3, IgH-cMaf, IgH-CCND1 5xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
F: Karyotype, (1)FISH in plasma cells G-banding,  1xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
G: Karyotype, (2)FISH in plasma cells G-banding, 2xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
H: Karyotype, del13q14, TP53, IgH-FGFR3 G-banding, 3xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
I: Karyotype, (4)FISH in plasma cells G-banding, 4xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
J: Karyotype, del13q14, TP53, IgH-FGFR3, IgH-cMaf, IgH-CCND1 G-banding, 5xFISH in plasma cells 1-2ml of bone marrow in heparin tube 15-25°C 7
WALDENSTROM/IgM-MGUS
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
BCL6/3q27 (all rearrangements) FISH 1-2ml of bone marrow/3-5ml of blood in heparin tube 15-25°C 5
c-MYC t(8q24) (all rearrangements) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη 15-25°C 5
del(13q)(14.3) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη 15-25°C 5
6q23 / MYB  FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη 15-25°C 5
ATM (11q22.3) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη 15-25°C 5
TP53 (17p deletion) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη 15-25°C 5
MYD88 L265P MLPA 1-2ml of bone marrow/3-5ml of blood in EDTA tube 15-25°C 5
 B-CELL LYMPHOMAS
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
BCL6 3q27 Αναδιατάξεις FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/ 4 τομές παραφίνης 4μm σε πλακάκι  5/7
C-MYC/(8q24) (various partners)  FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
IGH/c-MYC/CEP8 t(8;14)(q24;q32) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
CCND1(BCL1)-IGH /t(11;14)(q13q32) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
IgH-BCL2 t(14;18)(q32;q21) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
API2(BIRC3)/MALT1,t(11;18)(q21;q21) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
IGH-MALT1 t(14;18) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
Έλλειψη 7q21 FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
Τρισωμία 3  FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
Aπώλεια TP53 FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C/4 τομές παραφίνης 4μm σε πλακάκι  5/7
MYD88 L265P MLPA 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι γενικής αίματος με αντιπηκτικό EDTA/ βιοψία λεμφαδένα 15-25°C/ 6 τομές παραφίνης 10μm σε πλακάκι  5
Συνδυασμοί Αναλύσεων  Λεμφωμάτων Β κυττάρων  Method Specimen Type  Turnaround Time (business days) 
Α: Καρυότυπος & C-MYC(8q24)  G-banding και FISH  1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 15/5
Β: IGH-BCL1, IGH-BCL2, BCL6(3q27) 3xFISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
Γ: IGH-BCL2 & καρυότυπος PCR, G-banding 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
 ΛΕΜΦΩΜΑΤΑ T ΚΥΤΤΑΡΩΝ
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
7/7q-/i(7q) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
Τρισωμία 8 FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
ALK t(2p23) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
KMT2A (MLL)/ 11q23 Ανακατατάξεις FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
CDKN2A(P16)/CEN9 / -9/9p-/+9 FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
IgH t(14q32) FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
ΚΛΩΝΙΚΟΤΗΤΑ Β ΚΑΙ T
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
TCRγ clonality Multiplex PCR 3-5ml Αίματος/ Μυελού σε σωληνάκι γενικής αίματος με αντιπηκτικό EDTA/ βιοψία λεμφαδένα 15-25°C 5
TCRα/δ FISH 1-2ml Μυελού/3-5ml Αίματος σε σωληνάκι με ηπαρίνη/ βιοψία λεμφαδένα 15-25°C 5
IgH Κλωνικότητα Multiplex PCR 1-2ml Μυελού/3-5ml Αίματος  σε σωληνάκι γενικής αίματος με αντιπηκτικό EDTA 15-25°C 5

BioAnalytica-Genotype SA serves the healthcare market by offering Cytogenetics and Molecular Genetics tests, designed to answer questions related to diagnosis, prognosis and therapy selection for hematologic and solid tumor cancers.