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Contracted laboratory for Biomarkers

BIOANALYTICA GENOTYPE SA was established in December 2004 as a biotech startup aiming to provide specialised molecular cytogenetic research and application services to the biomedical Community.

 

Was funded by BIOANALYTICA SA, a leading stakeholder in the greek market for molecular diagnostics and laboratory infrastructure, and by the researcher Dr. Georgia Bardi, Associate Professor of Experimental Clinical Genetics at the Medical school of Lund University, Sweden and former Director of the Cytogenetics facility at Saint Savas Oncology hospital of Athens.

 

Is co-financed by the Greek General Secretariat of Research and Technology under the 3rd Community Support Program (03 Praxe 26).

 

 

PRENATAL GENETIC TESTING

PRENATAL GENETIC TESTING

PRENATAL-POSTNATAL GENETIC TESTING-GENETIC DISEASES
PRENATAL GENETIC TESTING
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Peripheral Blood Karyotype G-Banding 5 mL of peripheral blood in a heparin tube 15-25°C 15
    Cytogenetic Analysis of Miscarriage Products: Karyotype (in case of unsuccessful culture, analysis of aneuploidies with QF-PCR method) G-Banding /QF-PCR Miscarriage products in a sterile container with growth medium 21
 Molecular Karyotype Array CGH  2 mL of amniotic fluid in a sterile containter/10 mg of chorionic villi in a sterile container with growth medium + 3-5mL of blood in EDTA tubes from both parents  21
Molecular Analysis of a-chain Hemoglobinopathies (CE/IVD)   PCR-Reverse Hybridization (CE/IVD) 3-5mL of blood in EDTA tube
Μolecular Analysis of b-chain Hemoglobinopathies (CE/IVD) PCR-Reverse Hybridization (CE/IVD) 3-5mL of blood in EDTA tube 3
Detection of del 508 mutation in Cystic Fibrosis (CFTR) Real-Time PCR > 0,5 mL peripheral blood:  15-25°C
Mutations in Cystic Fibrosis  76,5% PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Mutations in Cystic Fibrosis gene Next Generation Sequencing > 0,5 mL peripheral blood:  15-25°C 10
NIPT GLARIGO (13, 18, 21, X/Y) NGS (CE-IVD) 10ml blood in Streck tubes 5
GENETIC ANALYSIS OF MALE INFERTILITY
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Peripheral Blood Karyotype G-Banding 5 mL of peripheral blood in a heparin tube 15-25°C 15
Parental Peripheral Blood Karyotyping G-Banding 5 mL of peripheral blood in a heparin tube 15-25°C 15
Y Chromosome Microdeletions (AZF) Multiplex PCR  3-5ml of blood in EDTA tube 5
Detection of del 508 mutation in Cystic Fibrosis (CFTR) Real-Time PCR > 0,5 mL peripheral blood:  15-25°C 2
Mutations in Cystic Fibrosis  76,5% PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Mutations in Cystic Fibrosis gene  Next Generation Sequencing > 0,5 mL peripheral blood:  15-25°C 10 
Molecular Analysis of Thrombophilia: (FACTOR ΙΙ (G20210A), FACTOR V (G1691A,R2 H1299A ), MTHFR (C677T,Α1298C), FACTOR ΧΙΙ (V34L), PAI-1, ApoB, ApoE, ΑCE, GPIIIa, fibrinogen-β)  PCR-Hybridization (CE/IVD) Peripheral blood(> 0,5 mL):  15-25°C
Molecular Analysis of Histocompatibility Antigens (HLA)  PCR-Hybridization (CE/IVD) Peripheral blood (> 0,5 mL):  15-25°C 10 
Molecular Testing of Non-Viral Factors (Chlamydia, Mycoplasma, Ureaplasma)  Real-Time PCR Any: 4°C <24h
Sperm DNA Fragmentation and Sperm Apoptosis FACS Sperm:  15-25°C 1
GENETIC ANALYSIS OF FEMALE INFERTILITY
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Peripheral Blood Karyotype G-Banding 5 mL of peripheral blood in a heparin tube 15-25°C 15
Parental Peripheral Blood Karyotyping G-Banding 5 mL of peripheral blood in a heparin tube 15-25°C 15
Molecular Analysis of Thrombophilia: (FACTOR ΙΙ (G20210A), FACTOR V (G1691A,R2 H1299A ), MTHFR (C677T,Α1298C), FACTOR ΧΙΙ (V34L), PAI-1, ApoB, ApoE, ΑCE, GPIIIa, fibrinogen-β) in cases of recurrent miscarriages PCR-Hybridization (CE/IVD) Peripheral blood(> 0,5 mL):  15-25°C
FRAGILE-X syndrome PCR-FRAGMENT ANALYSIS Peripheral blood (> 0,5 mL):  15-25°C 5
Molecular Analysis of Histocompatibility Antigens (HLA)  in cases of recurrent miscarriages PCR-Hybridization (CE/IVD) Peripheral blood (> 0,5 mL):  15-25°C 10 
NK Cells Flow Cytometry Peripheral blood (> 0,5 mL):  15-25°C 1
MOLECULAR ANALYSIS OF RARE HEREDITARY GENETIC DISEASES
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Molecular Karyotype Array CGH (Comparative Genomic hydridization) 3-5ml of blood in EDTA tube 21
Mutations in Cystic Fibrosisgene Next Generation Sequencing > 0,5 mL peripheral blood:  15-25°C 10
35delG Mutation (Bilateral Hearing Loss) Real-Time PCR > 0,5 mL peripheral blood:  15-25°C
SMA MLPA > 0,5 mL peripheral blood:  15-25°C 3
FAMILIAL ADRENAL HYPERPLASIA (CYP21A2) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
MODY (GCK, HNF1A, HNF4A, HNF1B, INS, ABCC8, KCNJ11) NGS > 0,5 mL peripheral blood:  15-25°C 10
STARGARDT SYNDROME (ABCA4, ELOVL4, CNGB) NGS > 0,5 mL peripheral blood:  15-25°C 10
DUCHENNE/BECKER MUSCULAR DYSTROPHY (DMD) NGS > 0,5 mL peripheral blood:  15-25°C 10
Familial Mediterranean Fever (12 mutations) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Familial Mediterranean Fever (all mutations) NGS > 0,5 mL peripheral blood:  15-25°C 10
HEMOCHROMATOSIS, HFE gene  (12 mutations: V53M, V59M, H63D, H63H, S65C, Q127H, P160delC, E168Q, E168X, W169X, C282Y, Q283P), TFR2 gene (4 mutations: E60X, M172K, Y250X, AVAQ594-597del), and FPN1 gene (2 mutations: Ν144Η, V162del) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Hemochromatosis (ALL TYPES): HFE, HFE2, HAMP, TFR2, SLC40A1) NGS ≥ 2 μg DNA or ≥ 2 ml of peripheral blood in EDTA tube 20 
THROMBOPHILIA
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
Factor V Mutation (V-Leiden) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Factor V Mutation  (R2 H1299A) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
Prothrombin Mutation                                             (Factor ΙΙ-G20210A) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Factor  XIII (V34L Mutation) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Homocysteine Mutation                                      (MTHFR, C677T) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Homocysteine Mutation                                      (MTHFR, Α1298C) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Plasminogen Activator Inhibitor-1   (PAI-1) Mutation  Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Glycoprotein Polymorphism GPIa Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
Polymorphism GPIIIa                                  (HPA1a/b, L33P) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Apolipoprotein E (APO E) Polymorphism   Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Apolipoprotein B Mutation ( R3500Q) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Apolipoprotein B Mutation  (R3531C) Real-Time PCR (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 4
Angiotensin-Converting Enzyme Mutation (ACE, I/D) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
Endothelial Nitric Oxide Synthase Polymorphism  786 T>C  PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
Lymphotoxin A Polymorphism                             804 C>A  PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
Fibrinogen B Mutation (-455G>A) PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
GENETIC PREDISPOSITION
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
 IL-28β Genotypes  Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C
AS680Ser Polymorphism of the FSH Receptor  Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C
codon8/15 Polymorphisms of the LH Receptor  PCR -RFLPs > 0,5 mL peripheral blood:  15-25°C
ESR1-PvuII Polymorphism of the Εra Receptor PCR -RFLPs > 0,5 mL peripheral blood:  15-25°C
Pro72Arg Polymorphism of P53  Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C
rs873330 T>C Polymorphism of P63  Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C
rs4648551 G>A and rs6695978 G>A Polymorphisms of P73 Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C 3
 rs929271 Τ>G  Polymorphism of LIF Real-Time PCR  > 0,5 mL peripheral blood:  15-25°C
rs3798220 Τ>C     Polymorphism of  LpA PCR/sequencing > 0,5 mL peripheral blood:  15-25°C
 rs10455872  A>G Polymorphism of LpA PCR/sequencing > 0,5 mL peripheral blood:  15-25°C
Detection of HLΑ Β-27 PCR -RFLPs > 0,5 mL peripheral blood:  15-25°C
HLA-A Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
HLA-B Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
HLA-C Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
  HLA-DRB1 Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C 3
 HLA-DQB1 Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
 HLA-DQA1 Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
HLA-DPB Typing PCR-Hybridization (CE/IVD) > 0,5 mL peripheral blood:  15-25°C
MISC TESTS - PANELS 
Test (genetic marker) Method Specimen Type  Turnaround Time (business days) 
DNA Isolation from common biological materials N/A Any  2  
DNA Isolation from difficult biological materials N/A Any  5
DNA Paternity Test PCR-Sequencing Peripheral Blood (>0,5 mL) or Cell Suspension:  15-25°C  5 
DNA Relationship Test PCR-Sequencing Peripheral Blood (>0,5 mL) or Cell Suspension:  15-25°C  5 
DNA Identification from difficult biological materials PCR-Sequencing Any  10 
THROMBOPHILIA PANEL-1: FACTOR ΙΙ (G20210A), FACTOR V (LEIDEN G1691A), MTHFR (C677T) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
THROMBOPHILIA PANEL-2: FACTOR ΙΙ (G20210A), FACTOR V (LEIDEN G1691A), MTHFR (C677T), GP1a PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
THROMBOPHILIA PANEL-3 (RISK OF THROMBOSIS): FACTOR ΙΙ (G20210A), FACTOR V (G1691A,R2 H1299A ), MTHFR (C677T,Α1298C), FACTOR ΧΙΙ (V34L), PAI-1, EPCR (A1,A3) - CVDT PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
THROMBOPHILIA PANEL-3a (RISK OF THROMBOSIS): FACTOR  V (R2 H1299A ), FACTOR ΧΙΙI (V34L), PAI-1, EPCR (A1,A3) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
THROMBOPHILIA PANEL-4 (RISK OF ATHEROSKLEROSIS): ΑCE, ApoB, ApoE, GPIIIa, FIBRINOGEN-β, eNOS (G894S, -786 T>C) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
THROMBOPHILIA PANEL-5 (CARDIOVASCULAR CONDITIONS): FACTOR ΙΙ (G20210A), FACTOR V (G1691A,R2 H1299A ), MTHFR (C677T,Α1298C), FACTOR ΧΙΙ (V34L), PAI-1, ApoB, ApoE, ΑCE, GPIIIa, FIBRINOGEN-β  - CVD PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C
MOLECULAR TYPING  HLA-CLASS I (A, B, C) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C  5 
MOLECULAR TYPING  HLA-CLASS II (DR, DQ, DP) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C  5
MOLECULAR TYPING  HLA-CLASS I/II (A, B, C, DR, DQ, DP) PCR-hybridization (CE/IVD) Peripheral Blood (>0,5 mL):  15-25°C  5 

BioAnalytica-Genotype SA serves the healthcare market by offering Cytogenetics and Molecular Genetics tests, designed to answer questions related to diagnosis, prognosis and therapy selection for hematologic and solid tumor cancers.